Pediatric anesthesia & critical care
Understanding time to peak effect of propofol as sole agent on bispectral index in children aged 2–12 years
Authors' conclusion
In children, the age and weight have an influence on time to peak effect of propofol. In the absence of opioids and benzodiazepines, time to peak effect was approximately 20% longer in children aged 8-12 years as compared to younger children.
Study context
- Population
- Healthy children aged 2–12 years for elective surgery, propofol as sole agent via TCI (Paedfusor model), induction to plasma target 7 μg.mL-1
- Participants
- 46 children
- Exposure
- Children aged 2-6 years vs 8-12 years
- Outcome
- Time to peak of propofol effect-site concentration (BIS as effect-site marker)
Methodological detailsnonlinear mixed-effects modelling
- Nonlinear mixed-effects modelling
Main finding
As reported in the abstract
Time to peak of propofol effect-site concentration
P < 0.01
Observational data: associations, not effects.
Further findings
Plasma effect-site equilibration rate constant (ke0)
- Heterogeneous distribution, median (per minute)
- 2.36
- IQR
- 2.05-2.93
- Range
- 0.83-7.31
- Weight-dependent effect in patients with weight below 45 kg
Original publication
Understanding time to peak effect of propofol as sole agent on bispectral index in children aged 2–12 years. Paediatr Anaesth. Published 31 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →