Using the nociception level index to compare the intraoperative antinociceptive effect of propofol and sevoflurane during clinical and experimental noxious stimulus in patients under general anesthesia
Authors' conclusion
Despite a precise intraoperative experimental and clinical protocol using the NOL index, propofol does not provide a higher level of antinociception during anesthesia or analgesia after surgery when compared to sevoflurane.
Study context
- Population
- Adults, ASA I to III, undergoing elective abdominal laparoscopic surgery under general anesthesia (GA)
- Participants
- 60 adults
- Comparison
- Propofol vs sevoflurane for induction and maintenance of GA
Methodological detailsprospective, monocentric
- Prospective
- Monocentric
Primary result
As reported in the abstract
- Antinociceptive properties of propofol and sevoflurane similar
Further findings
| Outcome | Propofol | Sevoflurane | P value |
|---|---|---|---|
| Delta NOL after tetanic stimulationHigher in the sevoflurane group | 39 ± 13 | 47 ± 15 | P = 0.04 |
Intraoperative and postoperative pain outcomes and opioid consumption
- Similar between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Using the nociception level index to compare the intraoperative antinociceptive effect of propofol and sevoflurane during clinical and experimental noxious stimulus in patients under general anesthesia. J Clin Anesth. Published 21 May 2024. doi:10.
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