Validity of the total Sequential Organ Failure Assessment (SOFA) score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study
Authors' conclusion
Different components of the SOFA score have different prognostic implications for older critically ill adults.
Study context
- Population
- Patients ≥ 80 years old acutely admitted to intensive care units (ICUs), 2018–2019analysed
- Participants
- 3,882 patients
- Comparison
- Organ failure by organ system vs none
- Primary endpoint
- Association between increasing severity of organ dysfunction and mortality
- Follow-up
- 30 days
Methodological details22 countries, consecutive patients, logistic regression
- 22 countries
- Consecutive patients
- Logistic regression
Primary result
As reported in the abstract
ICU mortality by organ failure (SOFA ≥ 3) per organ system
Adjusted odds ratio (95% CI)
Respiratory failure
1.53(1.29–1.81)
Cardiovascular failure
1.69(1.43–2.01)
Hepatic failure
1.74(0.97–3.15)
Renal failure
1.87(1.48–2.35)
Central nervous system failure
2.79(2.34–3.33)
Coagulation failure
2.72(1.66–4.48)
Per organ system, as printed
Further findings
Total SOFA score
- Median SOFA score among 3882 analysed patients (IQR: 4-9)
- 6
ICU mortality
- Mortality in the ICU
- 26.1% (95% CI 24.7-27.5%)
Mortality · day 30
- Mortality at day 30
- 38.7% (95% CI 37.1-40.2%)
Consecutive levels of cardiovascular organ dysfunction and ICU mortality
- aOR, cardiovascular SOFA 2 points
- 0.57 (95% CI 0.33-1.00)
- aOR, cardiovascular SOFA 3 points (0.79-1.30)
- 1.01
Original publication
Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study. Ann Intensive Care. Published 5 October 2023. doi:10.
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