Variations of SPI during outpatient laparoscopic cholecystectomy without muscle relaxants using ANI-guided remifentanil
Authors' conclusion
During laparoscopic cholecystectomy without muscle relaxants, remifentanil titrated to achieve a target ANI range of 50-80 provides SPI values with poor correlation ranging from 20 to 50, corresponding to adequate nociception-antinociception balance.
Study context
- Population
- Adults undergoing outpatient laparoscopic cholecystectomy without muscle relaxants, bilateral TAP block, remifentanil targeted to ANI 50–80 and desflurane MAC 0.8–1.2
- Participants
- 40 adults
- Outcome
- ANI and SPI values during surgery
Methodological detailsAll procedures were performed without muscle relaxants
- All procedures were performed without muscle relaxants
Main finding
As reported in the abstract
- ANI, mean ± SD, at induction
- 70 ± 12
- ANI, mean ± SD, at intubation (significant decrease)
- 57 ± 15
- ANI, mean ± SD, at extubation
- 56 ± 17
- SPI, mean ± SD, at induction
- 60 ± 15
- SPI, mean ± SD, at intubation (significant decrease)
- 38 ± 16
- SPI, mean ± SD, at extubation (increased)
- 73 ± 14
- Poor but significant negative linear relationship between SPI and ANI (r2; p < 0.001)
- 0.053
Observational data: associations, not effects.
Original publication
Variations of SPI during outpatient laparoscopic cholecystectomy without muscle relaxants using ANI-guided remifentanil. J Clin Monit Comput. Published 5 May 2025. doi:10.
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