Relationship between ANI and qNOX and between MAC and qCON during outpatient laparoscopic cholecystectomy using remifentanil and desflurane without muscle relaxants: a prospective observational preliminary study
Authors' conclusion
The qCON and qNOX monitoring seems informative during general anesthesia using desflurane and remifentanil without muscle relaxants in patients undergoing ambulatory laparoscopic cholecystectomy.
Study context
- Population
- Adults undergoing outpatient laparoscopic cholecystectomy under remifentanil and desflurane without muscle relaxants
- Exposure
- qNOX vs ANI and qCON vs MAC
- Outcome
- Relationships between monitoring indices
Methodological detailspreliminary study, Remifentanil targeted to ANI 50-80 and desflurane to MAC 0.8-1.2
- Preliminary study
- Remifentanil targeted to ANI 50-80 and desflurane to MAC 0.8-1.2
Main finding
As reported in the abstract
- Poor but significant negative linear relationship between ANI and qNOX, r2
- 0.07
- Negative linear relationship between qCON and MAC, r2
- 0.48
- Negative linear relationship between qNOX and remifentanil infusion rate, r2
- 0.13
- Linear mixed-effect regression r2, ANI-qNOX
- 0.65
- Linear mixed-effect regression r2, qCON-MAC
- 0.96
Observational data: associations, not effects.
Further findings
qNOX and qCON values over time
- Higher qNOX and qCON at induction and extubation; between 40 and 60 at all other time-points
- ANI between 50 and 80 during maintenance
Original publication
Relationship between ANI and qNOX and between MAC and qCON during outpatient laparoscopic cholecystectomy using remifentanil and desflurane without muscle relaxants: a prospective observational preliminary study. J Clin Monit Comput. Published 21 April 2022. doi:10.
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