Hemodynamics, fluids & transfusion
Volume of intraoperative normal saline versus lactated Ringer's solution on acute kidney injury: A secondary analysis of the SOLAR trial
Authors' conclusion
While saline administration clearly causes volume-dependent hyperchloremia, we found no evidence to support the theory that large volumes of saline provoke AKI.
Study context
- Population
- Adults having colorectal or orthopedic surgery at a large academic institution
- Participants
- 8,616 adults
- Comparison
- Normal saline vs Lactated Ringer's
- Primary endpoint
- Incidence of AKI as a function of intraoperative crystalloid volume (0-1, 1-2, 3-4, or 4+ liters) and type of crystalloid
Methodological detailssingle-centre, multiple cross-over cluster trial
- Single-centre
- Multiple cross-over cluster trial
Primary result
As reported in the abstract
AKI by crystalloid volume
- Risk of acute kidney injury (AKI) did not differ significantly with 0-1, 1-2, or 3-4 L saline or lactated Ringer's
- With 2-3 or > 4 L, lactated Ringer's had a higher risk of AKI than saline
Secondary outcomes
Postoperative serum chloride concentration · first 24 h
- Progressively greater plasma chloride with normal saline than lactated Ringer's across all volume categories
Original publication
Volume of intraoperative normal saline versus lactated Ringer's solution on acute kidney injury: A secondary analysis of the SOLAR trial. J Clin Anesth. Published 9 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →