Xenon anaesthesia is associated with a reduction in frontal electroencephalogram peak alpha frequency
Authors' conclusion
Xenon administration is associated with a reduction of peak alpha frequency in the frontal EEG.
Study context
- Population
- Participants from an RCT of xenon anaesthesia and a volunteer study of xenon administration11 RCT + 21 volunteers · an RCT of xenon anaesthesia 11
- Comparison
- Xenon administration vs awake baseline
- Outcome
- Frontal EEG peak alpha frequency
Methodological detailsEEG analysis of two cohorts, in silico computational modelling
- EEG analysis of two cohorts
- In silico computational modelling
Main finding
As reported in the abstract
Frontal peak alpha frequency, RCT cohort
P = 0.012
Further findings
Frontal peak alpha frequency, volunteer cohort
P = 0.001
In silico simulations (2 computational neuronal models)
- Antagonism of HCN2 and glutamatergic excitatory neurotransmission associated with reduced peak alpha frequency
Original publication
Xenon anaesthesia is associated with a reduction in frontal electroencephalogram peak alpha frequency. BJA Open. Published 1 December 2024. doi:10.
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