Cardiothoracic & vascular anesthesia
A clinical comparison of the effects of six disposable cardiopulmonary bypass circuits on bleeding and coagulation: a quality assurance project
Authors' conclusion
The findings of this quality assurance project suggest that current Health Canada-approved CPB circuits may have differential effects on coagulation and bleeding.
Study context
- Population
- Consecutive patients undergoing various types of cardiac surgery with cardiopulmonary bypass (CPB) over 12 months, Toronto General Hospital
- Participants
- 872 consecutive patients
- Exposure
- Six disposable CPB circuits compared with each other
- Outcome
- Bleeding, transfusion and hemostatic therapy
Methodological detailsretrospective cohort study, consecutive patients, single-centre, generalized estimating equations accounting for clustering by surgeon
- Retrospective cohort study
- Consecutive patients
- Single-centre
- Generalized estimating equations accounting for clustering by surgeon
Main finding
As reported in the abstract
- Significant differences between circuit types for all primary and secondary outcomes, accounting for surgeon, patient and procedural characteristics
Observational data: associations, not effects.
Secondary outcomes
Prebypass vs postbypass coagulation tests
- No major differences between the six types of circuit
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A clinical comparison of the effects of six disposable cardiopulmonary bypass circuits on bleeding and coagulation: a quality assurance project. Can J Anaesth. Published 18 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →