Cardiothoracic & vascular anesthesia
A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis
Authors' conclusion
When sugammadex was titrated to effect, the dose was usually less than the recommended dose, but it was more in some patients.
Study context
- Population
- Cardiac surgery patients receiving rocuroniumevaluated
- Participants
- 97 patients
- Outcome
- Sugammadex dose required to achieve TOFR 0.9 or greater
- Follow-up
- Conclusion of cardiac surgery
Methodological detailssugammadex titrated to effect, EMG monitoring, NMB monitored with electromyography in the ICU until sedation discontinued before extubation or for a maximum of 7 h
- Sugammadex titrated to effect
- EMG monitoring
- NMB monitored with electromyography in the ICU until sedation discontinued before extubation or for a maximum of 7 h
Main finding
As reported in the abstract
Sugammadex dose required for TOFR ≥0.9
Required less than the recommended dose
84 of 97
87%
Required more than the recommended dose
13
13%
Safety
| Outcome | Values |
|---|---|
| Recurrent paralysis requiring additional sugammadex (ICU monitoring) | Sugammadex 2 events |
Original publication
A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis. Anesthesiology. Published 7 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →