A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia
Methodological detailsproposed approach
- Proposed approach
Recommendations
As issued by the authors
Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) is the first line of testing for malignant hyperthermia susceptibility; sensitivity only up to 70%
Contracture testing may be used to rule out the disorder for some individuals
Stepwise approach using clinical history and assessment and interpretation of genetic variants to balance risks and benefits
Original publication
A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia. Anesthesiology. Published 10 March 2026. doi:10.
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