Anaesthetic drugs & techniques
A proposed North American approach for genetic testing of individuals at risk for malignant hyperthermia
Methodological detailsstatement, Affirmation of Value designation from the American Society of Anesthesiologists; endorsement from the Canadian Anesthesiologists' Society
- Statement
- Affirmation of Value designation from the American Society of Anesthesiologists; endorsement from the Canadian Anesthesiologists' Society
Recommendations
As issued by the authors
Genetic testing of RYR1, CACNA1S and STAC3 is the first line of testing for malignant hyperthermia susceptibility; sensitivity only up to 70%
Contracture testing may be used to rule out the disorder for some individuals
Stepwise approach using clinical history and assessment and interpretation of genetic variants to balance risks and benefits
Original publication
A proposed North American approach for genetic testing of individuals at risk for malignant hyperthermia. Can J Anaesth. Published 26 May 2026. doi:10.
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