Malignant Hyperthermia in Sweden: Clinical Presentations and Genetic Findings
Authors' conclusion
We found that MH reactions predominantly occur in young individuals and that case fatality has declined over recent decades, with no deaths reported in the past 20 years. Less than 40% of the genetically investigated MH families, corresponding to around 20% of all Swedish MH families, currently have an identified genetic diagnostic variant.
Study context
- Population
- Index cases of families investigated for malignant hyperthermia (MH) in the Swedish MH Registry since 1980544 families
- Participants
- 2,852 cases
- Outcome
- Clinical manifestations, demographics and genetic findings of index cases
Methodological detailsnational registry
- National registry
Main finding
As reported in the abstract
- MH confirmed (individuals)
- 1555
- Index cases with MH reaction history and confirmed MH
- 288
- Male, among these index cases
- 58%
- Age < 18 years, among these index cases
- 57%
- MH confirmed where masseter muscle spasm was only clinical sign
- 41%
- Overall case fatality following MH reaction
- 5.2%
- Fatal MH reactions reported since 2001
- 0
- Genetically investigated MH families
- 163
- Families with diagnostic variant
- 61
- Families with variant of unknown significance
- 23
Observational data: associations, not effects.
Original publication
Malignant Hyperthermia in Sweden: Clinical Presentations and Genetic Findings. Acta Anaesthesiol Scand. Published 13 May 2026. doi:10.
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