Cardiothoracic & vascular anaesthesia
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery
Primary resultResult — go to the resultRelative risk 0.93 95% CI 0.81–1.07Authors' conclusion
Among adults undergoing cardiac surgery, ANH did not reduce the number of patients receiving allogeneic red-cell transfusion.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass
- Participants
- 2,010 adults
- Comparison
- ANH vs usual care
- ANHn = 1,010
- Usual caren = 1,000reference
- Primary endpoint
- Transfusion of ≥1 unit of allogeneic red cells
- Follow-up
- During the hospital stay
Methodological detailsmultinational, single-blind, 32 centres, 11 countries
- Multinational
- Single-blind
- 32 centres, 11 countries
Primary result
As reported in the abstract
Relative risk
0.93
95% CI 0.81–1.07
P = 0.34
Events by treatment group
ANH vs Usual care
RR 0.93 (95% CI 0.81–1.07); P = 0.34
Secondary outcomes
Death within 30 days or during hospitalization
Safety
Surgery for postoperative bleeding
Surgery for postoperative bleeding
- Safety outcomes similar in the two groups
Original publication
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery. N Engl J Med. Published 12 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →