Cardiothoracic & vascular anesthesia
Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Hemodilution as a Blood Conservation Strategy in Cardiac Surgery
Authors' conclusion
RCTs reporting significant reductions in red blood cell transfusions with ANH exhibited greater statistical robustness, as indicated by higher FI and CFI values, compared with nonsignificant studies.
Study context
- Population
- Adults undergoing cardiac surgery28 RCTs
- Comparison
- Acute normovolemic hemodilution (ANH) vs standard care
Methodological detailsFragility Index analysis, Search of PubMed/MEDLINE, Cochrane Central Register of Controlled Trials and EMBASE from inception
- Fragility Index analysis
- Search of PubMed/MEDLINE, Cochrane Central Register of Controlled Trials and EMBASE from inception
Pooled result
As reported in the abstract
- Median Fragility Index (FI) for perioperative transfusion rates higher in nonsignificant studies (p ≥ 0.05) than in significant ones (p < 0.05)
- Median Continuous FI (CFI) for number of RBC units transfused higher in significant studies
Further pooled results
Trial characteristics
- Median sample size (patients)
- 75.8
- On-pump CABG, most common procedure
- 39.3%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Hemodilution as a Blood Conservation Strategy in Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 1 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →