Cardiothoracic & vascular anaesthesia
Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients: A Secondary Analysis of the Acute Normovolemic Hemodilution (ANH) Trial
Primary result · Occurrence of at least 1 allogeneic packed red blood cell (pRBC) transfusionResult — go to the resultRelative risk 0.87 95% CI 0.69–1.10Authors' conclusion
In this post hoc secondary analysis of a randomized clinical trial, ANH was not associated with a reduction in allogeneic pRBC transfusion among women undergoing cardiac surgery and was associated with more frequent intraoperative hypotension and longer ICU and hospital stay. These exploratory findings warrant confirmation in adequately powered studies specifically designed to evaluate female patients undergoing cardiac surgery.
Study context
- Population
- Female patients undergoing elective cardiac surgery with cardiopulmonary bypasswomen of 2010 patients in the original ANH trial, included in this analysis · ANH 219 · usual care 186
- Participants
- 405 patients
- Comparison
- Acute normovolemic hemodilution compared with usual care
- ANHn = 219
- Usual caren = 186reference
- Primary endpoint
- Occurrence of at least 1 allogeneic packed red blood cell (pRBC) transfusion
- Follow-up
- During the index hospitalization
Primary result
As reported in the abstract
Relative risk
0.87
95% CI 0.69–1.10
P = 0.24
By group
ANH vs usual care
RR 0.87 (95% CI 0.69–1.10); P = 0.24
Further findings
Age of participants
- Median (IQR) age
- 62 (54-69) years
Safety
| Outcome | ANH | Usual care | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Intraoperative hypotension | 16.0% | 4.8% | 3.30 (1.62–6.74) | P = 0.02 | |
| 0.10.31310Relative risk (log scale) |
| Outcome | Mean difference (hours) (95% CI) | P value | |
|---|---|---|---|
| ICU length of stay | 21.13 (1.89–40.38) | P = 0.03 | |
| −200204060Difference, hours (linear scale) |
| Outcome | Mean difference (days) (95% CI) | P value | |
|---|---|---|---|
| Hospital length of stay | 1.92 (0.14–3.70) | P = 0.04 | |
| −2024Difference, days (linear scale) |
Mortality and other postoperative complications
- No significant differences were observed
Original publication
Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients: A Secondary Analysis of the ANH Trial. JAMA Surg. Published 14 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →