A single center descriptive study of local anesthetic dose in knee arthroplasty: Was there evidence of local anesthetic systemic toxicity?
Authors' conclusion
Over the course of our study, we had 4527 knee arthroplasties with a median PAI and PNB local anesthetic dose that was 147% of the suggested maximum without any clear clinical evidence of a LAST event.
Study context
- Population
- Patients receiving both a periarticular injection (PAI) and a peripheral nerve block (PNB) for primary, revision, total, partial, unilateral or bilateral knee arthroplasty, major academic hospital, May 2018–November 2022
- Participants
- 4,527 knee arthroplasties
- Outcome
- Combined PAI and PNB local anesthetic dose
- Follow-up
- Study period
Methodological detailssingle-centre, descriptive
- Single-centre
- Descriptive
Main finding
As reported in the abstract
Patients receiving more than the suggested maximum dose of 3 mg/kg lean body weight
>75%
Median local anesthetic dose (IQR 3.5,5.9)
4.4 mg/kg
Median dose as % of suggested maximum (IQR 117,197)
147%
Observational data: associations, not effects.
Safety
- No conclusive evidence of local anesthetic systemic toxicity (LAST) among any patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A single center descriptive study of local anesthetic dose in knee arthroplasty: Was there evidence of local anesthetic systemic toxicity? J Clin Anesth. Published 28 June 2024. doi:10.
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