Cardiothoracic & vascular anesthesia
Abnormal Iron Status and Adverse Outcome After Elective Cardiac Surgery: A Prospective, Observational Multicenter Study
Main finding · PRBC transfusionResult — go to the resultAdjusted relative risk 1.2 95% CI 0.9–1.8Authors' conclusion
An abnormal iron status before elective cardiac surgery was associated with an increased risk of postoperative major complications but not with PRBC transfusion or a new onset of clinically significant disability.
Study context
- Population
- Patients aged 60 years and older undergoing elective on-pump cardiac surgery, 3 cardiac surgical centres in the Netherlands, 2019–2021
- Participants
- 427 patients · 3 centres
- Exposure
- Abnormal vs normal preoperative iron status
- Abnormal iron statusn = 193
- Outcome
- Packed red blood cell (PRBC) transfusion
- Follow-up
- 30 days
Methodological detailsmulticentre, Recruitment on hold March–May 2020 due to COVID-19
- Multicentre
- Recruitment on hold March–May 2020 due to COVID-19
Main finding
As reported in the abstract
Adjusted relative risk
1.2
95% CI 0.9–1.8
P = 0.227
Abnormal iron status vs Normal iron status
adjusted RR 1.2 (95% CI 0.9–1.8); P = 0.227
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted RR (95% CI) | P value | |
|---|---|---|---|
| Postoperative major complications (eg, AKI, sepsis) · 30 daysIncreased risk | 1.7 (1.1–2.5) | P = 0.012 | |
| New onset of clinically significant disability · 120 daysNot associated | 2.0 (0.9–4.6) | P = 0.098 | |
| 0.20.5125Adjusted relative risk (log scale) |
Prevalence of abnormal preoperative iron status
- Abnormal iron status (n = 193)
- 45.2%
- Iron deficiency (n = 117)
- 27.4%
Original publication
Abnormal Iron Status and Adverse Outcome After Elective Cardiac Surgery: A Prospective, Observational Multicenter Study. J Cardiothorac Vasc Anesth. Published 17 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →