ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study
Authors' conclusion
B blood group and O were associated with an increased risk of SAT and severe SAT.
Study context
- Population
- ICU patients diagnosed with sepsis, January 2014 to December 20229,113 screened
- Participants
- 6,296 patients
- Exposure
- ABO blood groups A, B, O vs AB
- Outcome
- SAT
- Follow-up
- First 72 hours of ICU admission
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each group vs ABOdds ratio (95% CI)
B
1.32(1.05–1.67)
O
1.37(1.09–1.72)
- Sepsis-associated thrombocytopenia (SAT) overall
- 2494 (39.6%)
- SAT significantly lower in AB vs other groups
- P = 0.032
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Severe SATA vs AB · multivariate analysis | 1.68 (1.16–2.42) | |
| Severe SATB vs AB · multivariate analysis | 1.74 (1.74–2.50) | |
| Severe SATO vs AB · multivariate analysis | 1.72 (1.20–2.48) | |
| 0.512Odds ratio (log scale) |
- Severe SAT — Severe SAT overall
- 712 (11.3%)
- Severe SAT — AB less likely to experience severe SAT
- p = 0.028
Original publication
ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study. Crit Care Med. Published 15 November 2024. doi:10.
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