Haemodynamics, fluids & transfusion
Alterations in arterial pressure waveform morphology following volume loading versus vasopressor administration in critically ill patients
Main finding · Pulse-pressure-normalized systolic AUC (pre- vs post-intervention)Result — go to the resultMedian paired difference 4.6 ms 95% CI 1.9–7.9Authors' conclusion
Arterial waveform morphology exhibited different patterns of change following blood return versus phenylephrine administration, particularly in the systolic descending phase.
Study context
- Population
- Adult ICU patients, April 2022–June 2023, with increased mean arterial pressure (MAP) after blood return or phenylephrine
- Participants
- 26 vs 20
- Exposure
- Volume loading vs vasopressor
- Volumen = 26
- Pressorn = 20
- Outcome
- Changes in 21 arterial waveform-derived features and normalized parameters at peak MAP vs baseline
- Follow-up
- One minute before to four minutes after the intervention
Main finding
As reported in the abstract
Pulse-pressure-normalized systolic AUC (pre- vs post-intervention) · peak MAP
Median paired difference
4.6 ms
95% CI 1.9–7.9
P = 0.0038
Volume loading (blood return during hemodiafiltration discontinuation) vs vasopressor (IV phenylephrine)
median paired difference 4.6 ms (95% CI 1.9–7.9); P = 0.0038
Observational data: associations, not effects.
Further findings
Normalized systolic AUC during systolic descending phase
| Median paired difference (ms) (95% CI) | P value | ||
|---|---|---|---|
| Volume[1.1-9.5] | 4.4 (2.7–9.1) | P = 0.00021 | |
| −50510Difference, ms (linear scale) |
Systolic descending duration
- Significantly prolonged in the Volume group; no significant change in the Pressor group
Original publication
Alterations in arterial pressure waveform morphology following volume loading versus vasopressor administration in critically ill patients. J Clin Monit Comput. Published 14 August 2026. doi:10.
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