Cardiothoracic & vascular anesthesia
Angiopoietin-2 is associated with capillary leak and predicts complications after cardiac surgery
Authors' conclusion
Capillary leak and subsequent edema formation are relevant problems after cardiac surgery. Levels of angiopoietin-2 in combination with extracellular water show promising potential to predict postoperative complications after cardiac surgery.
Study context
- Population
- Cardiac surgery patients at a tertiary academic medical center
- Participants
- 405 patients
- Outcome
- Association of angiopoietin-2 with extracellular water and common postoperative complications
Methodological detailsmultidisciplinary, single-centre
- Multidisciplinary
- Single-centre
Main finding
As reported in the abstract
- Extracellular water increased postoperatively, 20 ± 6 preoperatively to 29 ± 7L on POD 2
- P < 0.001
- Angiopoietin-2 rose concomitantly, correlation with extracellular water by time points (r)
- 0.959
- Each 1 ng/mL increase in angiopoietin-2 associated with increase in extracellular water (L), adjusted for risk factors of edema
- 0.24
- Angiopoietin-2 and AKI (OR 1.095, 95% CI 1.032, 1.169)
- P = 0.004
Observational data: associations, not effects.
Further findings
Inflammatory (IL-6, IL-8, CRP) and endothelial biomarkers (VE-Cadherin, syndecan-1, ICAM-1)
- Increased, suggestive of capillary leak
Machine learning prediction of postoperative complications
- Complications predicted when capillary leak added to standard risk factors
Original publication
Angiopoietin-2 is associated with capillary leak and predicts complications after cardiac surgery. Ann Intensive Care. Published 8 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →