Assessing the use of the Index of Consciousness (IoC) as a monitoring tool for the sedative effects of ciprofol during general anesthesia induction: a prospective observational study
Main finding · Agreement and predictive accuracy for loss of responsivenessResult — go to the resultMean difference - 0.4308 95% CI - 19.47 to 18.61Authors' conclusion
The IoC1 is highly consistent with the BIS in the assessment of the sedative effects of ciprofol during general anesthesia induction.
Study context
- Population
- Patients aged 18 to 65 years undergoing noncardiac or noncranial elective surgery under GA with ciprofol induction
- Participants
- 130 patients
- Exposure
- IoC1 vs BIS for monitoring ciprofol sedation during GA induction
- Outcome
- Consistency (Bland-Altman mean difference, 95% LOA) and accuracy (ROC for loss of responsiveness) of IoC1 vs BIS
- Follow-up
- T1 to T8 during GA induction
Main finding
As reported in the abstract
Agreement and predictive accuracy for loss of responsiveness · T1 to T8
Mean difference
- 0.4308
95% CI - 19.47 to 18.61
P = 0.6664
By group
IoC1
- AUC
- 0.9821 (95% CI 0.9741 to 0.9900)
- Optimal threshold
- 91.5
- Sensitivity
- 94.6%
- Specificity
- 96.0%
BIS
- AUC
- 0.9855 (95% CI 0.9789 to 0.9922)
- Optimal threshold
- 82.5
- Sensitivity
- 99.2%
- Specificity
- 93.7%
AUC
IoC10.9821 (95% CI 0.9741 to 0.9900)
BIS0.9855 (95% CI 0.9789 to 0.9922)
Optimal threshold
IoC191.5
BIS82.5
Sensitivity
IoC194.6%
BIS99.2%
Specificity
IoC196.0%
BIS93.7%
Observational data: associations, not effects.
Original publication
Assessing the use of the Index of Consciousness (IoC) as a monitoring tool for the sedative effects of ciprofol during general anesthesia induction: a prospective observational study. Perioper Med (Lond). Published 6 January 2025. doi:10.
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