Hemodynamics, fluids & transfusion

Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis

J Clin Monit ComputPublished Prospective observational study

Authors' conclusion

During LBNP-induced hypovolemia, there were reciprocal changes in UL&LL bioimpedance. These changes reflected hemodynamic compensatory mechanisms to hypovolemia.

Study context

Population
Healthy volunteers undergoing gradual Lower body negative Pressure (LBNP)-induced hypovolemia (baseline, −15, −30, −45, −60 mmHg, recovery at −30 mmHg and baseline)
Participants
26 healthy volunteers
Outcome
Changes in upper (UL) and lower (LL) extremity bioimpedance during LBNP-induced hypovolemia

Main finding

As reported in the abstract

UL and LL bioimpedance during LBNP-induced hypovolemia

Correlation of estimated blood loss with UL bioimpedance (R)

0.97

Correlation of estimated blood loss with LL bioimpedance (R)

- 0.97

Observational data: associations, not effects.

Further findings

UL and LL bioimpedance during recovery phases

Significant increase in LL bioimpedance and reduction in UL bioimpedance

Original publication

Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis. J Clin Monit Comput. Published 15 November 2023. doi:10.1007/s10877-023-01098-y

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