Cardiothoracic & vascular anesthesia
Association Between Changes in Norepinephrine Infusion Rate and Urinary Oxygen Tension After Cardiac Surgery
Authors' conclusion
In patients recovering from on-pump cardiac surgery, changes in norepinephrine dose are associated with reciprocal changes in urinary PO2, potentially reflecting an effect of norepinephrine on renal medullary oxygenation.
Study context
- Population
- Patients recovering from on-pump cardiac surgery in a surgical intensive care unit (ICU)nonconsecutive sample
- Participants
- 93 patients
- Exposure
- Increase vs decrease in norepinephrine infusion rate
- Outcome
- Change in urinary PO2 from baseline
- Follow-up
- 30-to-60 minutes
Methodological detailssingle centre
- Single centre
Main finding
As reported in the abstract
| Group | Value | Baseline urinary PO2 |
|---|---|---|
| NE increase | least squares mean decrease 1.8 (SE 0.5) mmHg | 25.1 ± 1.1 mmHg |
| NE decrease | least squares mean increase 2.6 (SE 0.5) mmHg | 22.7 ± 1.2 mmHg |
Value
NE increaseleast squares mean decrease 1.8 (SE 0.5) mmHg
NE decreaseleast squares mean increase 2.6 (SE 0.5) mmHg
Baseline urinary PO2
NE increase25.1 ± 1.1 mmHg
NE decrease22.7 ± 1.2 mmHg
Observational data: associations, not effects.
Further findings
Vasopressor use in ICU
Urinary PO2 after epinephrine dose decrease (n = 21)
- No significant change in urinary PO2
- Insufficient observations for epinephrine increase (n = 11) or vasopressin changes (n <4)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Changes in Norepinephrine Infusion Rate and Urinary Oxygen Tension After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 11 November 2022. doi:10.
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