Cardiothoracic & vascular anesthesia
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
Authors' conclusion
Diaphragmatic dysfunction after adult cardiovascular surgery was significantly associated with longer duration of mechanical ventilation and higher reintubation.
Study context
- Population
- Adults admitted to ICU intubated after cardiovascular surgery, tertiary university hospitalanalysed
- Participants
- 153 adults
- Exposure
- Diaphragmatic dysfunction vs normal diaphragmatic motion
- Diaphragmatic dysfunctionn = 49
- Outcome
- Weaning off mechanical ventilation (duration from ICU admission to weaning)
Methodological detailssingle-centre
- Single-centre
Main finding
Duration of mechanical ventilation
Adjusted subdistribution hazard ratio
0.63
95% CI 0.43–0.92
By group
Diaphragmatic dysfunction vs Normal
adjusted subdistribution HR 0.63 (95% CI 0.43–0.92)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Diaphragmatic dysfunction | Normal | Estimate | P value | |
|---|---|---|---|---|---|
| ReintubationUnivariate logistic regression | 12.2% | 2.9% | unadjusted OR 4.70 (95% CI 1.12–19.65) | P = 0.034 | |
| All-cause death · follow-up maximum 6.5 yearsTendency to higher death | 18.4% | 9.6% | aHR 1.64 (95% CI 0.59–4.53) | ||
| Time to improvement of diaphragm position on chest radiographMedian, days | 14 (IQR 6–29) | 5 (IQR 2–10) | adjusted subdistribution HR 0.54 (95% CI 0.38–0.77) | ||
| 0.050.21520Ratio (log scale) |
Original publication
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study. J Intensive Care. Published 12 September 2023. doi:10.
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