Hemodynamics, fluids & transfusion
The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery ( PREVENTT ) trial
Study context
- Population
- Patients undergoing major abdominal surgery in the PREVENTT trial, by baseline iron status (absolute iron deficiency ferritin <30 μg.l-1; functional ferritin 30–100 μg.l-1 or transferrin saturation < 20%; remainder non-iron deficient)
- Participants
- 452 patients
- Comparison
- Intravenous iron vs placebo, by pre-operative iron status
- Primary endpoint
- Co-primary: blood transfusion or death, and number of blood transfusions
- Follow-up
- Randomisation to 30 days postoperatively
Methodological detailssubgroup analysis, interaction analysis
- Subgroup analysis
- Interaction analysis
Primary result
As reported in the abstract
Blood transfusion or death and number of blood transfusions, by baseline iron status subgroup · 30 days
- IV iron vs placebo did not differentially reduce death or blood transfusion across subgroups by ferritin (interaction P)
- p = 0.33
- Same, by transferrin saturation (interaction P)
- p = 0.13
- Same, by ferritin and transferrin saturation combined (interaction P)
- p = 0.45
- Number of blood transfusions, interaction P by ferritin, transferrin saturation, combined
- p = 0.06, 0.29, and 0.39
Secondary outcomes
| Outcome | Mean difference (g.l-1) (95% CI) | |
|---|---|---|
| Change in pre-operative haemoglobin (subgroup)Intravenous iron vs Placebo · absolute iron deficiency | 8.9 (5.3–12.5) | |
| Change in pre-operative haemoglobin (subgroup)Intravenous iron vs Placebo · functional iron deficiency | 2.8 (−0.1 to 5.7) | |
| −5051015Difference, g.l-1 (linear scale) |
Prevalence of iron deficiency at randomisation
- Any iron deficiency
- 369/452 [82%]
- Absolute iron deficiency
- 144/452 [32%]
- Functional iron deficiency
- 225/452 [50%]
Change in pre-operative haemoglobin (subgroup)
- Little change in non-iron deficient patients
Postoperative complications and hospital LOS
- No beneficial effect of IV iron vs placebo, regardless of iron deficiency metric
Original publication
The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery ( PREVENTT ) trial. Anaesthesia. Published 8 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →