Cardiothoracic & vascular anesthesia
Associations Between Nonanemic Iron Deficiency and Postoperative Outcomes in Cardiac Surgery: A Systematic Review and Meta-Analysis
Authors' conclusion
Acknowledging these limitations, the presence of preoperative nonanemic iron deficiency was not associated with a change in the primary outcome of length of hospital stay, or any patient-centered secondary outcome compared to those without iron deficiency. There was an association with increased requirement for allogeneic red blood cell transfusion, but this did not impact the reported patient-centered outcomes.
Study context
- Population
- Adults undergoing cardiac surgery
- Participants
- 2,683 adults · 8 studies
- Comparison
- Nonanemic iron deficiency vs iron-replete
- Outcome
- Length of acute hospital stay
Methodological detailsmeta-regression, ROBINS-E risk of bias, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE), Quality of evidence rated "low" or "very low" for all outcomes (GRADE)
- Meta-regression
- ROBINS-E risk of bias
- GRADE
- Quality of evidence rated "low" or "very low" for all outcomes (GRADE)
Pooled result
As reported in the abstract
- No significant association between nonanemic iron deficiency and length of hospital stay
Further pooled results
Requirement for allogeneic RBC transfusion
| OR (95% CI) | P value | ||
|---|---|---|---|
| Nonanemic iron deficiencyI2 2.8% · quality of evidence low or very low (GRADE) | 1.39 (1.16–1.68) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Other secondary outcomes (ICU LOS, RBC units transfused, DAH at POD 30 and 90, all-cause complications, infection, mortality, readmission)
- No significant association with nonanemic iron deficiency
Original publication
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