Cardiothoracic & vascular anesthesia
Association Between Loop Diuretics and Mortality in Patients With Cardiac Surgery–Associated Acute Kidney Injury: A Retrospective Propensity Score–Weighted Analysis
Authors' conclusion
LD use is associated with lower hospital and ICU mortality in CS-AKI patients in general.
Study context
- Population
- Patients with cardiac surgery–associated AKI (CS-AKI), Medical Information Mart for Intensive Care III
- Participants
- 5,478 patients
- Exposure
- Postoperative loop diuretic use in ICU vs no use
- LD usen = 4,150
- No LD usen = 1,328reference
- Outcome
- In-hospital mortality and ICU mortality (time-to-event, multivariable Cox models)
Methodological detailspropensity score–weighted (inverse probability weighting), MIMIC-III database
- Propensity score–weighted (inverse probability weighting)
- MIMIC-III database
Main finding
As reported in the abstract
In-hospital mortality
P < 0.001
- Adjusted HR (multivariable Cox), in-hospital mortality
- 0.428 (95% CI, 0.374-0.489)
- Inverse probability weighting (IPW) HR, in-hospital mortality
- 0.434 (95% CI, 0.376-0.502)
Observational data: associations, not effects.
Further findings
ICU mortality (co-primary) · crude rates
P < 0.001
- ICU mortality (co-primary) — Adjusted HR (multivariable Cox), ICU mortality
- 0.278 (95% CI, 0.238-0.327)
- ICU mortality (co-primary) — IPW HR, ICU mortality
- 0.296 (95% CI, 0.251-0.349)
Association by fluid balance (subgroup)
- Association may differ with fluid balance
- P value for interaction < .001
Original publication
Association Between Loop Diuretics and Mortality in Patients With Cardiac Surgery–Associated Acute Kidney Injury: A Retrospective Propensity Score–Weighted Analysis. Anesth Analg. Published 27 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →