Cardiothoracic & vascular anesthesia
Intraoperative FiO2 and risk of impaired postoperative oxygenation in lung resection: A propensity score-weighted analysis
Main findingResult — go to the resultOdds ratio 1.84 95 % CI 1.60–2.12Authors' conclusion
Such higher FiO2 was associated with an increased risk of impaired postoperative oxygenation - a clinically relevant manifestation of lung injury or dysfunction.
Study context
- Population
- Lung resection patients with good intraoperative oxygenation (median intraoperative SpO2 ≥ 95 %), 2 US academic hospitals
- Participants
- 2,936 patients
- Exposure
- Higher vs lower median intraoperative FiO2
- Higher FiO2n = 2,171
- Outcome
- Impaired postoperative oxygenation: ≥1 of SpO2 < 92 %, imputed PaO2/FiO2 < 300 mmHg (at least twice within 24 h), or intensive oxygen therapy (mechanical ventilation, > 50 % oxygen or high-flow oxygen)
- Follow-up
- Within 7 postoperative days
Methodological detailspre-specified, registry-based, propensity score-weighted, two academic hospitals
- Pre-specified
- Registry-based
- Propensity score-weighted
- Two academic hospitals
Main finding
As reported in the abstract
Odds ratio
1.84
95 % CI 1.60–2.12
P < 0.001
Events by group
Higher FiO2 vs Lower FiO2
OR 1.84 (95 % CI 1.60–2.12); P < 0.001
Observational data: associations, not effects.
Original publication
Intraoperative FiO2 and risk of impaired postoperative oxygenation in lung resection: A propensity score-weighted analysis. J Clin Anesth. Published 3 January 2025. doi:10.
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