Cardiothoracic & vascular anesthesia
Association of Glutamate Infusion With Risk of Acute Kidney Injury After Coronary Artery Bypass Surgery: A Pooled Analysis of 2 Randomized Clinical Trials
An erratum to this article was published (JAMA Netw Open, 2 Feb 2026 ↗)
Pooled resultResult — go to the resultRelative risk 0.49 95% CI 0.29–0.83Authors' conclusion
In this pooled analysis of 2 randomized clinical trials, infusion of glutamate was associated with a markedly lower risk of AKI after CABG among patients without diabetes.
Study context
- Population
- Patients without DM undergoing coronary artery bypass graft (CABG) (with or without valve procedure) with acute coronary syndrome, LV ejection fraction ≤0.30 or EuroSCORE II ≥3.0, 5 Swedish cardiac surgery centres
- Participants
- 791 patients · 2 RCTs
- Comparison
- Glutamate infusion vs saline
- Glutamaten = 391
- Controln = 400reference
- Outcome
- Acute kidney injury (AKI) (postoperative plasma creatinine increase ≥50%, RIFLE Risk stage or higher)
Methodological detailsdouble-blind, multicentre, prospective
- Double-blind
- Multicentre
- Prospective
Pooled result
As reported in the abstract
Relative risk
0.49
95% CI 0.29–0.83
Glutamate vs Control
RR 0.49 (95% CI 0.29–0.83)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| AKI (multivariable analysis) | 0.47 (0.26–0.86) | |
| 0.20.5125Odds ratio (log scale) |
Postoperative mortality · ≤30 days
Events
| Outcome | Glutamate | Control |
|---|---|---|
| Dialysis required | 2 | 5 |
Safety
Stroke · ≤24 hours
Original publication
Association of Glutamate Infusion With Risk of Acute Kidney Injury After Coronary Artery Bypass Surgery: A Pooled Analysis of 2 Randomized Clinical Trials. JAMA Netw Open. Published 2 January 2024. doi:10.
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