Cardiothoracic & vascular anesthesia
Glutamate infusion associated with reduced rises of p‐Copeptin after coronary surgery: Substudy of GLUTAMICS II
Authors' conclusion
Glutamate did not reduce rises of p-Copeptin significantly after moderate to high-risk CABG. However, glutamate was associated with reduced rises of p-Copeptin among patients without diabetes.
Study context
- Population
- Patients with left ventricular ejection fraction ≤0.30 or EuroSCORE II ≥3.0 undergoing CABG ± valve procedure48% had diabetes
- Participants
- 181 patients
- Comparison
- IV L-glutamic acid infusion vs saline
- Primary endpoint
- Increase in plasma Copeptin (p-Copeptin) from preoperative level to POD1
- Follow-up
- POD1
Methodological detailsprespecified substudy, double-blind
- Prespecified substudy
- Double-blind
Primary result
As reported in the abstract
- P-Copeptin increased postoperatively, highest on POD1, without significant inter-group differences
Further findings
Rise in p-Copeptin from preoperative level to POD1 (patients without diabetes) · significantly reduced in the glutamate group
P = 0.02
Postoperative mortality ≤30 days · did not differ
P = 0.50
| Outcome | P value |
|---|---|
| P-Copeptin level (patients without diabetes) · POD1 and POD 3Significantly lower in the Glutamate group on POD1 | P = 0.02 |
| P-Copeptin level (patients without diabetes) · POD1 and POD 3Significantly lower in the Glutamate group on POD 3 | P = 0.02 |
P-Copeptin level (patients without diabetes) · POD1 and POD 3
- P-Copeptin did not differ preoperatively
Safety
Postoperative stroke ≤24 h · did not differ
P = 0.25
Original publication
Glutamate infusion associated with reduced rises of p‐Copeptin after coronary surgery: Substudy of GLUTAMICS II. Acta Anaesthesiol Scand. Published 26 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →