Cardiothoracic & vascular anesthesia
Association of Impedance Aggregometry-Measured Platelet Aggregation With Thromboembolic Events in Patients Who Undergo Carotid Endarterectomy: A Pilot Study
Authors' conclusion
Because the ADP test was independently associated with perioperative stroke/TIA, the assessment of platelet reactivity using Multiplate may offer potential utility in monitoring patients undergoing CEA.
Study context
- Population
- Patients undergoing carotid endarterectomy (CEA), university hospital, November 2020–October 2022of 474 CEA patients
- Participants
- 131 patients
- Comparison
- Preoperative Multiplate platelet function tests (TRAP, ADP, ASPI) for discriminating perioperative stroke/TIA
- Outcome
- Discrimination of perioperative thromboembolic stroke/TIA
Methodological detailspilot study, single-centre
- Pilot study
- Single-centre
Performance
As reported in the abstract
| Test or model | Cut-off | Specificity | Sensitivity | NPV | PPV |
|---|---|---|---|---|---|
| ADP | >72 U | 87% | 68% | 99% | 15% |
ADP
Cut-off>72 U
Specificity87%
Sensitivity68%
NPV99%
PPV15%
Further findings
Factors independently associated with perioperative stroke/TIA (LASSO regression)
- ADP >72 U and need for shunt during CEA the only 2 independent variables
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Impedance Aggregometry-Measured Platelet Aggregation With Thromboembolic Events in Patients Who Undergo Carotid Endarterectomy: A Pilot Study. J Cardiothorac Vasc Anesth. Published 5 December 2023. doi:10.
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