Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study
Authors' conclusion
Findings from this cohort study suggest that a healthy sleep pattern may reduce the risk of developing sepsis, particularly among younger individuals.
Study context
- Population
- UK Biobank participants free of sepsis at baseline13,357 (3.26%) sepsis cases
- Participants
- 409,570 participants
- Exposure
- Healthy sleep score 5 vs 0-1
- 0 to 1n = 9,942reference
- 2n = 46,270
- 3n = 115,272
- 4n = 150,522
- 5n = 87,564
- Outcome
- Incident sepsis
- Follow-up
- Mean 13.54 years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Each one-point increase in the sleep score5% lower risk of developing sepsis
0.95(0.93–0.97)
Sleep score 5 vs Sleep score 0-1multivariate-adjusted
0.76(0.69–0.83)
Observational data: associations, not effects.
Further findings
Incident sepsis by age (subgroup)
- Negative correlation stronger in age < 60 years than older
- P for interaction < 0.001
Sepsis-related death and critical care admission
- Healthy sleep pattern not associated
Original publication
Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study. Crit Care. Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →