Association of serum uric acid, gout with incident sepsis: a large population-based prospective cohort study from UK Biobank
Authors' conclusion
Higher SUA levels, HUA, and gout were associated with a higher incidence of sepsis in this observational cohort. Among patients who developed sepsis, asymptomatic HUA was associated with modestly higher short-term mortality, whereas this risk was not observed in the gout group.
Study context
- Population
- UK Biobank participants16,210 incident sepsis cases
- Participants
- 466,611 participants
- Exposure
- Asymptomatic HUA and gout vs normal uric acid
- Outcome
- Incident sepsis
- Follow-up
- Median 14.53 years
Methodological detailspopulation-based, UK Biobank, multivariable Cox proportional hazards models, Fine-Gray competing-risk sensitivity analyses
- Population-based
- UK Biobank
- Multivariable Cox proportional hazards models
- Fine-Gray competing-risk sensitivity analyses
Main finding
As reported in the abstract
Each group vs normal uric acidHazard ratio (95% CI)P value
Asymptomatic HUA
1.31(1.26–1.36)
P < 0.001Gout
1.35(1.25–1.46)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident sepsis by SUA quartile (Q1 reference)Q2 vs Q1 | 1.06 (1.01–1.12) | ||
| Incident sepsis by SUA quartile (Q1 reference)Q3 vs Q1 | 1.12 (1.07–1.19) | ||
| Incident sepsis by SUA quartile (Q1 reference)Q4 vs Q1 | 1.27 (1.20–1.34) | ||
| 28-day all-cause mortality among sepsis patients · 28 daysAsymptomatic HUA vs Normal uric acid · fully adjusted | 1.17 (1.07–1.29) | P < 0.01 | |
| 0.512Hazard ratio (log scale) |
Serum uric acid (SUA) and sepsis risk (restricted cubic spline)
- Nonlinear association; P for nonlinearity
- < 0.001
- Risk increasing above approximately (μmol/L)
- 384.8
28-day all-cause mortality among sepsis patients
- Baseline gout: association not significant after adjustment
Original publication
Association of serum uric acid, gout with incident sepsis: a large population-based prospective cohort study from UK Biobank. J Intensive Care. Published 28 August 2026. doi:10.
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