Association of vitamin D with sepsis incidence and mortality: a large population-based prospective cohort study
Main finding · Incident sepsisResult — go to the resultAdjusted hazard ratio 1.28 CI 1.22–1.34Authors' conclusion
Lower serum 25(OH)D concentrations were associated with an increased incidence of sepsis and higher mortality.
Study context
- Population
- UK Biobank participants15,452 incident sepsis cases
- Exposure
- Serum 25D < 10 ng/mL vs > 20 ng/mL
- Outcome
- Incident sepsis
- Follow-up
- Mean 14 years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Adjusted hazard ratio
1.28
CI 1.22–1.34
< 10 ng/mL vs > 20 ng/mL
aHR 1.28 (CI 1.22–1.34)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| 28-day mortality | 1.14 (1.02–1.27) | |
| 60-day mortality | 1.11 (1.01–1.23) | |
| 1-year mortality | 1.10 (1.02–1.19) | |
| 0.512Adjusted hazard ratio (log scale) |
Incident sepsis (subgroups: women; BMI < 25 kg/m²)
- Association stronger among women and participants with BMI < 25 kg/m²
Original publication
Association of vitamin D with sepsis incidence and mortality: a large population-based prospective cohort study. Crit Care. Published 29 March 2026. doi:10.
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