Cardiothoracic & vascular anesthesia
Association of postoperative delirium with haemodynamic determinants of cerebral perfusion pressure during cardiac surgery: a retrospective cohort study
Main finding · Delirium vs time in cerebral hypoperfusion zoneResult — go to the resultAdjusted odds ratio 1.02 95% CI 1.00–1.03Authors' conclusion
Delirium was associated with a zone of low cerebral perfusion pressure in adjusted models and individual ranges of low and high cerebral perfusion pressures.
Study context
- Population
- Patients undergoing cardiac surgery
- Participants
- 1,759 patients
- Exposure
- Time spent in mean arterial pressure (MAP)/central venous pressure (CVP) haemodynamic ranges and zones
- Outcome
- Postoperative delirium (CAM-ICU)
Main finding
Delirium vs time in cerebral hypoperfusion zone
Adjusted odds ratio
1.02
95% CI 1.00–1.03
P = 0.04
Time in cerebral hypoperfusion zone
aOR 1.02 (95% CI 1.00–1.03); P = 0.04
As reported in the abstract
- Delirium incidence
- 345 (19.6%)
Observational data: associations, not effects.
Further findings
Simulated redistribution of MAP/CVP exposures
- Simulated reductions of time in hypoperfusion and hyperperfusion zones reduced delirium, particularly with prolonged exposures
Individual haemodynamic ranges
- Delirium associated with time in high CVP/low MAP (hypoperfusion) and high MAP/low CVP (hyperperfusion) ranges
Original publication
Association of postoperative delirium with haemodynamic determinants of cerebral perfusion pressure during cardiac surgery: a retrospective cohort study. Br J Anaesth. Published 5 May 2026. doi:10.
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