Cardiothoracic & vascular anesthesia
Fine-Mapping the Association of Acute Kidney Injury With Mean Arterial and Central Venous Pressures During Coronary Artery Bypass Surgery
Authors' conclusion
Fine-mapping identified narrow ranges of MAP, CVP, and joint MAP/CVP associated with both AKI risk and protection.
Study context
- Population
- Adults undergoing coronary artery bypass surgery
- Participants
- 1,199 adults
- Exposure
- Minutes spent in narrow MAP, CVP and joint MAP/CVP ranges
- Outcome
- AKI
Methodological detailsmultivariable regression, adjusted for multiple comparisons
- Multivariable regression
- Adjusted for multiple comparisons
Main finding
As reported in the abstract
AKI per 5 min spent in each hemodynamic range
- MAP 45 to 50 mm Hg · significantly increased risk
- aOR 1.18; P = 0.002
- MAP 50 to 55 mm Hg · significantly increased risk
- aOR 1.13; P = 0.001
- MAP 55 to 60 mm Hg · significantly increased risk
- aOR 1.06; P = 0.001
- MAP 90 to 95 mm Hg · significantly decreased risk
- aOR 0.85; P < 0.001
- CVP 16 to 18 mm Hg · significantly increased risk
- aOR 1.07; P = . 002
- CVP 4 to 6 mm Hg · significantly decreased risk
- aOR 0.97; P = . 025
Observational data: associations, not effects.
Further findings
Joint MAP/CVP ranges
- Risk decreased as CVP decreased within every MAP range; significantly lower for CVP <8 and MAP >75
5 MAP/CVP hemodynamic zones
- Protection from acute kidney injury (AKI) in zone 1 (high MAP/low CVP); increased risk in zones 3 to 5 (low MAP/high CVP)
Original publication
Fine-Mapping the Association of Acute Kidney Injury With Mean Arterial and Central Venous Pressures During Coronary Artery Bypass Surgery. Anesth Analg. Published 17 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →