Cardiothoracic & vascular anesthesia
Associations Between Base Excess, Alactic Base Excess, and Kidney Function Deterioration in Patients Undergoing Coronary Artery Bypass Grafting Surgery: A Retrospective Cohort Study
Authors' conclusion
Lower BE and aBE values are associated with an increased risk of kidney function deterioration in patients undergoing CABG surgery.
Study context
- Population
- Patients undergoing coronary artery bypass grafting (CABG) surgery (Medical Information Mart for Intensive Care IV (MIMIC-IV) database)
- Participants
- 5,634 patients
- Exposure
- Lower vs higher baseline base excess (BE) and alactic BE (aBE)
- Outcome
- Kidney function deterioration (new-onset AKI and increased severity of AKI)
Methodological detailsMIMIC-IV database, multivariate logistic regression
- MIMIC-IV database
- Multivariate logistic regression
Main finding
As reported in the abstract
Kidney function deterioration
Odds ratio (95% CI)
BE ≤2.61
1.22(1.05–1.41)
aBE ≤1.038
1.19(1.02–1.38)
Observational data: associations, not effects.
Further findings
New-onset acute kidney injury (AKI)
| OR (95% CI) | ||
|---|---|---|
| aBE ≤1.038 | 1.26 (1.01–1.57) | |
| 0.512Odds ratio (log scale) |
AKI recovery (patients with AKI at baseline) (subgroup)
| OR (95% CI) | ||
|---|---|---|
| BE ≤2.61 | 1.88 (1.47–2.41) | |
| aBE ≤1.038 | 1.82 (1.42–2.33) | |
| 0.512Odds ratio (log scale) |
Kidney function deterioration (subgroups)
- Associations of lower BE and aBE with deterioration also found in age ≥65 years, males, no CKD, vasopressors given, and no loop diuretics, nephrotoxic antibiotics, blood infusions or acetaminophen
Original publication
Associations Between Base Excess, Alactic Base Excess, and Kidney Function Deterioration in Patients Undergoing Coronary Artery Bypass Grafting Surgery: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 21 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →