Cardiothoracic & vascular anesthesia
Hyperoxia-induced deterioration of diastolic function in anaesthetised patients with coronary artery disease – Randomised crossover trial
Authors' conclusion
Although the response of biventricular systolic variables is dependent on systolic function at normoxaemia, diastolic function consistently worsens under hyperoxia.
Study context
- Population
- Patients with coronary artery disease scheduled for elective CABG under GA
- Comparison
- FiO2 0.8 vs 0.3, randomised order
- Primary endpoint
- Changes in 3D peak strain (TOE)
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Systolic function (3D peak strain)
- No statistical difference in systolic function between normoxaemia and hyperoxia
Further findings
| Outcome | Hyperoxia | Normoxaemia | P value |
|---|---|---|---|
| Averaged E/e'Diastolic function worsened during hyperoxia | 8.6 (not stated 2.6) | 8.2 (not stated 2.4) | P = 0.01 |
| E/A ratio | 1.4 (not stated 0.4) | 1.3 (not stated 0.4) | P = 0.01 |
Left ventricular (LV) global longitudinal strain (GLS) response by normoxaemic LV-GLS (subgroup)
- Normoxaemic LV-GLS poorer than cut-off (>−15.4%): improved with hyperoxia
- P < 0.01
- Normoxaemic LV-GLS <−15.4%: worsened with hyperoxia
- P < 0.01
Right ventricular GLS response by normoxaemic RV GLS (subgroup)
- Same pattern as LV GLS, cut-off −24.1%
Original publication
Hyperoxia-induced deterioration of diastolic function in anaesthetised patients with coronary artery disease – Randomised crossover trial. BJA Open. Published 27 April 2023. doi:10.
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