Cardiothoracic & vascular anaesthesia
Effects of hyperoxia on systolic and diastolic function assessed by strain analysis in patients with coronary artery disease during general anaesthesia
Authors' conclusion
In patients with coronary artery disease, mean GCS deteriorated with hyperoxia under general anaesthesia. Furthermore, circumferential strain based diastolic markers delineated a global and regional effect of hyperoxia on myocardial function.
Study context
- Population
- Patients with coronary artery disease undergoing elective CABG under GAdatasets analysed
- Participants
- 99 patients
- Comparison
- Hyperoxic vs normoxaemic inspired oxygen fractions during GA
- Primary endpoint
- Change in 2D global systolic circumferential strain (GCS) on TOE
Methodological detailssingle tertiary centre
- Single tertiary centre
Primary result
As reported in the abstract
2D GCS
P = 0.041
Further findings
Ejection fraction · unchanged
P = 0.190
| Outcome | Hyperoxia | Normoxaemia | P value |
|---|---|---|---|
| 2D global systolic longitudinal strain (GLS)Unchanged | −12.4% | 12.7% | P = 0.307 |
Individual GCS response to hyperoxia
- Relevant worsening during hyperoxia
- 30%
- Improvement during hyperoxia
- 14%
- P
- P < 0.001
- Responses heterogeneous, depended on baseline systolic function
GCS change vs count of myocardial segments with stenotic coronary lesions
- More stenotic segments associated with improved GCS during hyperoxia (r)
- −0.26
- P
- P = 0.009
Global and regional diastolic function
- Deteriorated under hyperoxia
Original publication
Effects of hyperoxia on systolic and diastolic function assessed by strain analysis in patients with coronary artery disease during general anaesthesia. Eur J Anaesthesiol Intensive Care. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →