Cardiothoracic & vascular anesthesia
Carboxyhemoglobin in Cardiac Surgery Patients and Its Association with Risk Factors and Biomarkers of Hemolysis
Authors' conclusion
CO-Hb may represent a readily obtainable and frequently measured biomarker that has a moderate association with known biomarkers of and risk factors for hemolysis in on-pump cardiac surgery patients.
Study context
- Population
- On-pump cardiac surgery patients38,487 carboxyhemoglobin (CO-Hb) measurements
- Participants
- 1,735 patients
- Outcome
- Temporal changes in CO-Hb levels after cardiac surgery
Methodological detailsdescriptive
- Descriptive
Main finding
As reported in the abstract
Peak CO-Hb vs baseline · median of 17 hours after initiation of surgery
- Peak CO-Hb level times higher than baseline
- 2.1
- P value
- P < .001
Observational data: associations, not effects.
Further findings
Factors independently associated with higher peak CO-Hb (generalized linear model)
- Age
- P < 0.001
- Preoperative respiratory disease
- P = 0.001
- New York Heart Association Class IV
- P = 0.019
- Number of packed RBC transfused
- P < 0.001
- Duration of cardiopulmonary bypass (CPB)
- P = 0.002
Correlation of peak CO-Hb with postoperative total bilirubin
- Rho
- 0.27
- P value
- P < 0.001
Original publication
Carboxyhemoglobin in Cardiac Surgery Patients and Its Association with Risk Factors and Biomarkers of Hemolysis. Anesth Analg. Published 6 March 2024. doi:10.
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