CCL14 testing to guide clinical practice in patients with acute kidney injury (AKI): Results from an international expert panel
Authors' conclusion
Most recommendations for care of patients with stage 2-3 by an international panel of experts were strongly modified by CCL14 test results.
Study context
- Population
- Patients at risk for persistent stage 3 AKI (lasting 72 hours or longer)
- Participants
- 12 experts
- Comparison
- Clinical action recommendations before vs after urinary CCL14 testing
- Outcome
- Association between strength and direction of recommendations for 11 guideline-based clinical actions and CCL14 results
Methodological detailsinternational expert panel, modified Delphi process, Likert scale rating, case-based before and after CCL14 testing, 11 clinical actions based on international guidelines rated on a Likert scale for each case before and after CCL14 testing
- International expert panel
- Modified Delphi process
- Likert scale rating
- Case-based before and after CCL14 testing
- 11 clinical actions based on international guidelines rated on a Likert scale for each case before and after CCL14 testing
Main finding
As reported in the abstract
Strength and direction of clinical recommendations
- Strongly influenced by CCL14 results (interaction)
- P < 0.001
- Recommendations for clinical actions significantly impacted by CCL14 results (low vs highest CCL14 risk category, P < 0.001)
- Nine (82%)
Original publication
CCL14 testing to guide clinical practice in patients with AKI: Results from an international expert panel. J Crit Care. Published 27 April 2024. doi:10.
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