Cardiothoracic & vascular anesthesia
Chronic kidney disease progression after cardiac surgery: a retrospective multicentre study
Authors' conclusion
Cardiac surgery patients with preexisting CKD face substantial kidney disease progression, especially early after discharge.
Study context
- Population
- Adult cardiac surgery patients with preexisting chronic kidney disease (CKD) (KDIGO stages G3a-G5), Odense (2000–2022) and Aarhus (2008–2024) University Hospitals3,512 (12.8%) preexisting CKD
- Participants
- 27,483 patients
- Exposure
- G1-2 vs G3a vs G3b vs G4 vs G5
- Outcome
- CKD progression and kidney failure in patients with kidney impairment before cardiac surgery
Methodological detailscompeting risk analysis
- Competing risk analysis
Main finding
As reported in the abstract
Cumulative 5-yr incidence (preexisting CKD) · 5 yr
- Rapid progression
- 38.7%
- CKD stage progression
- 23.8%
- Kidney failure
- 5.5%
- Events within first year: rapid progression
- 43%
- Events within first year: kidney failure
- 26%
- Events within first year: CKD progression
- 18%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Five-year survival by baseline kidney function · 5 yr | Stages G1-2 86.1% · Stage G3a 70.6% · Stage G3b 61.4% · Stage G4 45.7% · Stage G5 51.9% |
Risk factors for CKD progression
- Males aged ≤70 yr with stage G4 CKD who developed postoperative AKI faced highest risks across all outcomes
Original publication
Chronic kidney disease progression after cardiac surgery: a retrospective multicentre study. BJA Open. Published 9 December 2025. doi:10.
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