Comparative Effectiveness of Albumin vs No Albumin on Renal Replacement Therapy and Mortality in Patients With Septic Shock and Renal Impairment
Main finding · RRT or in-hospital mortalityResult — go to the resultOdds ratio 1.29 95% CI 1.14–1.47Authors' conclusion
In patients with septic shock and kidney impairment on hospital admission, early albumin use may be associated with an increased composite outcome of RRT or in-hospital mortality.
Study context
- Population
- Adults with septic shock and kidney impairment on hospital admission, 220 US community and teaching hospitals
- Participants
- 9,988 adults · 220 hospitals
- Exposure
- Early albumin vs no albumin
- Albuminn = 2,059
- No albuminn = 7,929reference
- Outcome
- Composite of:
- Renal replacement therapy (RRT)
- In-hospital mortality
Methodological detailsmulticenter, inverse probability-of-treatment weighted
- Multicenter
- Inverse probability-of-treatment weighted
Main finding
RRT or in-hospital mortality
Odds ratio
1.29
95% CI 1.14–1.47
P < 0.001
By group
Albumin vs No albumin
OR 1.29 (95% CI 1.14–1.47); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| RRT or in-hospital mortality, 5% albumin5% albumin vs No albumin | 1.07 (0.84–1.37) | |
| RRT or in-hospital mortality, 25% albumin25% albumin vs No albumin · significantly increased risk | 1.43 (1.16–1.76) | |
| 0.512Odds ratio (log scale) |
Original publication
Comparative Effectiveness of Albumin vs No Albumin on Renal Replacement Therapy and Mortality in Patients With Septic Shock and Renal Impairment. Chest. Published 18 October 2024. doi:10.
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