Hemodynamics, fluids & transfusion
Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis
Authors' conclusion
Aggressive intravenous hydration increased the mortality risk in severe AP, and fluid-related complication risk in both severe and non-severe AP.
Study context
- Population
- Patients with severe and non-severe acute pancreatitis (AP)
- Participants
- 953 patients · 9 randomized controlled trials (RCTs)
- Comparison
- Aggressive vs non-aggressive intravenous hydration
- Outcome
- All-cause mortality
Methodological detailsrandom-effects model, sensitivity analyses
- Random-effects model
- Sensitivity analyses
Pooled result
As reported in the abstract
Aggressive vs Non-aggressivePooled relative risk (95% CI)
Severe AP
2.45(1.37–4.40)
Non-severe AP; inconclusive
2.26(0.54–9.44)
Safety
| Outcome | Pooled RR (95% CI) | |
|---|---|---|
| Fluid-related complicationsAggressive vs Non-aggressive · severe AP | 2.22 (1.36–3.63) | |
| Fluid-related complicationsAggressive vs Non-aggressive · non-severe AP | 3.25 (1.53–6.93) | |
| 0.10.31310Pooled relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis. Crit Care. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →