Hemodynamics, fluids & transfusion
Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study
Authors' conclusion
Administration of rTM in patients with AP complicated by DIC was associated with lower in-hospital mortality.
Study context
- Population
- Adults hospitalised with acute pancreatitis (AP) and disseminated intravascular coagulation (DIC) who survived at least 3 days, Japanese Diagnosis Procedure Combination national inpatient database, July 2010–March 2022
- Participants
- 10,238 adults · 1,868 matched pairs
- Exposure
- rTM within 3 days of admission vs no rTM
- rTMn = 2,001
- non-rTMn = 8,237reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide, propensity score-matched
- Nationwide
- Propensity score-matched
Main finding
As reported in the abstract
Each group vs non-rTMRisk difference (95% CI)
rTM
−4.2%(−6.6% to −1.7%)
Each group vs non-rTMRelative risk (95% CI)
rTM
0.79(0.69–0.91)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study. Crit Care Med. Published 2 January 2026. doi:10.
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