Cardiothoracic & vascular anesthesia
Copeptin Levels During Cardiac Surgery
Authors' conclusion
The elevated levels during CPB suggest a strong activation of the arginine vasopressin system, with peak levels exceeding those seen in septic shock.
Study context
- Population
- Adults undergoing open cardiac surgery with cardiopulmonary bypass (CPB), tertiary care hospital57 analysed
- Participants
- 61 adults
- Exposure
- Above reference vs Below reference
- Outcome
- Copeptin levels
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Preoperative copeptin, median (IQR 3.9-11.0)
- 6.6 pmol/L
- After sternotomy, median (IQR 15.0-66.0 pmol/L); significant increase from preoperative, p ≤ 0.001
- 27 pmol/L
- Peak 60 minutes after CPB initiation, median (IQR 163-446 pmol/L)
- 286 pmol/L
- At CPB termination, median (IQR 136.0-346.0 pmol/L); no significant drop until then, p ≤ 0.001
- 179.5 pmol/L
- 4 days postoperatively, median (IQR 7.2-19.0 pmol/L); significantly higher than preoperative, p ≤ 0.001
- 11.5 pmol/L
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Copeptin Levels During Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 11 February 2025. doi:10.
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