COVID-19 and the Genetics of Inflammation
Authors' conclusion
The current literature supports the hypothesis that host genetic factors affect vulnerability to severe COVID-19.
Study context
- Population
- Studies examining inherited genetic variation or acquired clonal hematopoiesis (CH) mutations in severe COVID-19
- Outcome
- Genetic predispositions to severe COVID-19
Methodological detailsPubMed literature search, qualitative assessment, narrative synthesis
- PubMed literature search
- Qualitative assessment
- Narrative synthesis
Main finding
As reported in the abstract
- Genetic variants affecting inflammatory responses may increase susceptibility to severe COVID-19
- Genome-wide association and candidate gene studies identified inherited mutations likely altering cytokine and interferon secretion and lung-specific immunity
- Role of CH more uncertain; types of acquired mutations and their differential influence on immune cell function must be considered
Original publication
COVID-19 and the Genetics of Inflammation. Crit Care Med. Published 20 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →