Cytomegalovirus reactivation in the lower respiratory tract as an independent risk factor for mortality in critically Ill patients
Main finding · ICU mortalityResult — go to the resultAdjusted subdistribution hazard ratio 2.28 95% CI 1.46–3.56Authors' conclusion
Cytomegalovirus reactivation in the LRT is associated with poor outcomes in critically ill patients.
Study context
- Population
- Critically ill patients admitted to a medical intensive care unit (ICU) at a tertiary referral center in South Korea, January 2021–June 2023median age 68 years
- Participants
- 322 patients
- Exposure
- CMV reactivation in lower respiratory tract (LRT) vs no reactivation
- Cytomegalovirus reactivationn = 145
- Outcome
- ICU mortality
Methodological detailssingle-centre, multivariable Fine-Gray model
- Single-centre
- Multivariable Fine-Gray model
Main finding
As reported in the abstract
Adjusted subdistribution hazard ratio
2.28
95% CI 1.46–3.56
Cytomegalovirus reactivation vs No reactivation
aSHR 2.28 (95% CI 1.46–3.56)
Observational data: associations, not effects.
Further findings
| Outcome | aSHR (95% CI) | |
|---|---|---|
| In-hospital mortality | 2.00 (1.44–2.78) | |
| Mortality · 30-day | 2.11 (1.42–3.13) | |
| Mortality · 90-day | 2.05 (1.45–2.88) | |
| 0.20.5125Adjusted subdistribution hazard ratio (log scale) |
ICU mortality with anti-cytomegalovirus therapy (subgroups)
- Anti-CMV therapy associated with reduced ICU mortality in patients with radiologic findings suggestive of CMV pneumonia
- P for interaction = 0.001
- Anti-CMV therapy linked to increased mortality in patients with positive bacterial cultures
- P for interaction = 0.002
Original publication
Cytomegalovirus reactivation in the lower respiratory tract as an independent risk factor for mortality in critically Ill patients. Crit Care. Published 2 May 2025. doi:10.
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