Haemodynamics, fluids & transfusion
Deferring Arterial Catheterization in Critically Ill Patients with Shock
Primary result · Death from any causeResult — go to the resultAdjusted risk difference −3.2 percentage points 95% CI −8.9 to 2.5Authors' conclusion
Among patients with shock, results for death from any cause at day 28 indicated that management without early arterial catheter insertion was noninferior to early catheter insertion.
Study context
- Population
- Patients with shock admitted to an ICU within the past 24 hours
- Participants
- 504 vs 502
- Comparison
- Noninvasive BP monitoring vs early arterial catheter insertion
- Noninvasive strategyn = 504
- Invasive strategyn = 502reference
- Primary endpoint
- Death from any cause (non-inferiority margin 5 percentage points)
- Follow-up
- Day 28
Methodological detailsmulticentre, open-label, non-inferiority
- Multicentre
- Open-label
- Non-inferiority
Primary result
Death from any cause · 28 days
Adjusted risk difference
−3.2 percentage points
95% CI −8.9 to 2.5
P = 0.006 for non-inferiority
Events by treatment group
Noninvasive strategy vs Invasive strategy
adjusted risk difference −3.2 percentage points (95% CI −8.9 to 2.5); P for non-inferiority = 0.006
As reported in the abstract
Further findings
Arterial catheter insertion
Safety
≥1 day of pain or discomfort related to the BP-monitoring device
Hematoma or hemorrhage related to the arterial catheter
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Deferring Arterial Catheterization in Critically Ill Patients with Shock. N Engl J Med. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →