Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
Authors' conclusion
DIC appears to be strongly associated with the risk of developing the more severe form of AKI (stage 3 of the KDIGO classification, RRT requirement), even after adjustment for severity and other relevant factors.
Study context
- Population
- Adults (≥18 y) in ICU with infection-related hypotension requiring vasopressor (septic shock), without terminal CKD, Strasbourg University Hospital
- Participants
- 350 adults
- Exposure
- Disseminated intravascular coagulation (DIC) vs no DIC
- DICn = 129
- Outcome
- Acute kidney injury (AKI) occurrence, severity (KDIGO) and evolution (major adverse kidney events)
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
AKI
P < 0.005
Observational data: associations, not effects.
Further findings
KDIGO stage 3 AKI
P < 0.001
AKI requiring RRT · during ICU stay
P < 0.001
28-day mortality
P < 0.001
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| KDIGO stage 3 AKIAdjusted for confounding factors | 2.74 (1.53–4.91) | P < 0.001 | |
| AKI requiring RRT · during ICU stayAdjusted for confounding factors | 2.82 (1.53–5.2) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Median
| Outcome | DIC | No DIC | P value |
|---|---|---|---|
| SAPS II | 64 | 56 | P < 0.001 |
Original publication
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock. Ann Intensive Care. Published 1 December 2023. doi:10.
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